The Effect of Cilazapril and Aspirin on the Neuroendocrine System and Cardiac Function after Myocardial Infarction in Rats

Objective:To compare the effects of ACEI,aspirin,and combination of ACEI and aspirin on cardiac function and activity of neuroendocrine system in a model of myocardical infarction in rats.Methods:Myocardial infarction was induced in56Wistar male rats by ligation of the anterior descending coronary artery.Sham-operated rats served as controls(group A).One day after the operation,rats were randomized into4groups,group C(Cilazapril),group D(Aspirin),group E(Cilazapril and Aspirin),group B which did not re-ceive any drug treatment.After treated for two weeks,these rats were sacrificed.The levels of plasma an-giotensionⅡ,6-keto-PGF1αand endothelin were measured.Results:Compared with group A,there was a significantly difference in cardiac function among the four experimental groups.Furthermore,in group C and E,the cardiac functions were improved compared with that in group B.There was no significant difference between group C and E,and group B and D.Compared with group A,the plasma hormones(AngⅡ,ET-1)in group B were significantly increased,but they were reduced in group C and E.Compared with group A,the plasma hormone of6-keto-PGF1αwas decreased in group B.Conclusion:Cilazapril can improve the cardiac function of postinfarcted heart by depression the concentration of angⅡand the ET-1,and inhibition degra-dation of bradyknin.Aspirin has no effect on the cardiac function.Combination of Cilazapril and aspirin has no effect on Cilazapril.