The empirical study of rhBNP on the rabbits with chronic heart failure

Objective To study the effects of recombinant human brain natriuretic peptide(rhBNP) on the cardiac hemodynamics and heart function in the rabbits with chronic heart failure.Methods Rabbits with chronic heart failure were induced by damaging aortic valve of rabbits with ductus.Cardiovascular functional indicators were determined using echocardiography after five weeks.Rabbits with heart failure were divided to three groups randomly,and were given rhBNP,nitroprusside sodium and placebo(glucose) to treat.Cardiovascular functional indicators of rabbits were detected with echocardiography before and after therapy.The same three drugs were given after a week,and the change of hemodynamic parameter was observed before and after therapy.Results LVEF of it remarkably increased that rabbits with heart failure that were treated by rhBNP(LVEF: 0.63±0.06 vs 0.70 ±0.07);LVESV and diameter of LA was significantly reduced [LVESV:(2.1±0.7)ml vs(1.2±0.9)ml、LAD:(11.0±1.9)mm vs(10.1 ±1.8)mm].The change of CO wasn't obvious.LVEF,LVESV and LAD weren't conspicuous variation in nitroprusside sodium and placebo groups.The detecting of hemodynamic parameter indicated that remarkable changes appeared in the group of rhBNP [LVEDP:(19.1±2.8)mm Hg vs(6.4±5.9)mm Hg;DBP:(72.6±6.3)mm Hg vs(64.6±6.1)mm Hg(P0.05)].SBP,DBP,MAP,LVSP and LVEDP all decreased in group of nitroprusside sodium,but the variation of LVSP and SBP was more obvious.These parameter weren't change in group of placebo.Conclusion The study and research indicated that rhBNP can increase LVEF and decrease LVESV and diameter of LA;and it can reduce the pre-load and after-load in these rabbits of heart failure.Diastolic blood pressure and mean arterial pressure significantly reduced;but the decrease of LVEDP is more obvious.