Change of serum neuron-specific enolase level in children with severe hand-foot-mouth disease

Objective To study the change of serum neuron-specific enolase level in children with severe hand-foot-mouth disease and provide scientific basement for treatment.Methods 40 children with hand-foot-mouth disease(HFMD) and 20 children with simply cryptorchidism or hernia were investigated from April to June in 2009 in the research.They were divided into three groups:common HFMD group(n=20),severe HFMD group(n=20) and control group(n=20).Children with severe HFMD involved nervous system without cardiopulmonary function damage,and they received intravenous immunoglobulin(IVIG) at a dosage of 1 g/(kg.d) respectively on the first and next day after admission.The level of NSE was detected by enzyme-linked immunosorbent assay.Pediatric critical illness scores(PCIS)were completed on first day after admission in the severe HFMD group.Results The levels of NSE in common HFMD group,severe HFMD group before IVIG,severe HFMD group after IVIG and control group were 6.95±1.57ng/ml,8.80±2.24ng/ml,8.00±1.97ng/ml and 6.60±1.70ng/ml respectively.The level of NSE in severe HFMD group were higher than that in control group and common HFMD group(P 0.01).There was no significant difference on the levels of NSE before and after IVIG(P 0.05).PCIS was significantly positively correlated with NSE(r=0.530,P0.05).Conclusion The serum level of NSE could reflect the severity of HFMD.