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Progress in Kerationcyte Growth Factor

Xin Huang

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Abstract

Keratinocyte growth factor(KGF),a member of fibroblast growth factor(FGF),exerts proliferative and differenting effects on a variety of epithelial cells via binding to a specific FGF receptor. KGF gene expression is subject to positive and negative regulation. A fine balance of the regulation is important for normal function of KGF. Results have suggested that KGF play important roles in several aspects: the development of tissues and organs; prevent wound and facilitate wound healing; involvement in tissues malignant transformation.

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What this paper is about

Keratinocyte growth factor(KGF),a member of fibroblast growth factor(FGF),exerts proliferative and differenting effects on a variety of epithelial cells via binding to a specific FGF receptor. KGF gene expression is subject to positive and negative regulation. A fine balance of the regulation is important for normal function of KGF. Results have suggested that KGF play important roles in several aspects: the development of tissues and organs; prevent wound and facilitate wound healing; involvement in tissues malignant transformation.

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Available abstract

Keratinocyte growth factor(KGF),a member of fibroblast growth factor(FGF),exerts proliferative and differenting effects on a variety of epithelial cells via binding to a specific FGF receptor. KGF gene expression is subject to positive and negative regulation. A fine balance of the regulation is important for normal function of KGF. Results have suggested that KGF play important roles in several aspects: the development of tissues and organs; prevent wound and facilitate wound healing; involvement in tissues malignant transformation.

Key concepts: Keratinocyte growth factor, Fibroblast growth factor, Cell biology, FGF10, Wound healing, Fibroblast growth factor receptor 1, Growth factor, Fibroblast growth factor receptor

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