Mechanism of Anti-atherosclerosis Treatment by Amlodipine on Experimental Rabbits

Objective To investigate the mechanism of treatment of anti atherosclerosis by amlodipine. Methods To establish rabbit model of atherosclerosis, involing the treatment groups 1,2,3 the treatment control group, the empty control group. Plasma nitric oxide (NO) and serum endothelin (ET) were measured during this experiment regularly. Results The average plasma NO in the treatment groups 1,2,3, the treatment control group, the empty control group were 4.71±0.35, 4.62±0.48, 3.71±0.56, 2.12±0.34, 6.72±0.37 mmol/l. The results of plasma NO were increased after treatment by amlodipine significantly (P0.01). The average serum ET in those groups were 302.11±46.21, 284.32±37.25, 357.79±34.18, 1835.83±26.65, 107.24±24.8Pg/ml. The results of serum ET were decreased after treatment by amlodipine significantly (P0.01). Conclusion Amlodipine has the effect of anti atherosclerosis. The mechanism maybe contacted with increased plasma NO and decreased serum ET.