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2006•International Journal of Pathology and Clinical MedicineRequires access

Relationship between osteopontin-related moleculars and tumor metastasis

Sheng‐Long Ye

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Abstract

Osteopontin and its related molecules are closely associated with tumor metastasis.Transcriptional factors interact with promoter elements(e.g.RAE,Tcf-4or AP-1 binding sequences,RE-1) to regulate the expression of osteopontin.Osteopontin participates many processes of tumor metastasis through enhancing cell adhesion,increasing the secretion of MMPs or uPA,activating the receptors of growth factors and promoting angiogenesis.The mechanisms of these molecules faciliating tumor metastasis are discussed below.

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What this paper is about

Osteopontin and its related molecules are closely associated with tumor metastasis.Transcriptional factors interact with promoter elements(e.g.RAE,Tcf-4or AP-1 binding sequences,RE-1) to regulate the expression of osteopontin.Osteopontin participates many processes of tumor metastasis through enhancing cell adhesion,increasing the secretion of MMPs or uPA,activating the receptors of growth factors and promoting angiogenesis.The mechanisms of these molecules faciliating tumor metastasis are discussed below.

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Available abstract

Osteopontin and its related molecules are closely associated with tumor metastasis.Transcriptional factors interact with promoter elements(e.g.RAE,Tcf-4or AP-1 binding sequences,RE-1) to regulate the expression of osteopontin.Osteopontin participates many processes of tumor metastasis through enhancing cell adhesion,increasing the secretion of MMPs or uPA,activating the receptors of growth factors and promoting angiogenesis.The mechanisms of these molecules faciliating tumor metastasis are discussed below.

Key concepts: Osteopontin, Metastasis, Angiogenesis, Cancer research, Matrix metalloproteinase, Tumor progression, Cell adhesion molecule, Biology

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