Relationship between Depression and Stroke-specific Quality of Life in Sub-acute Period in Patients with Cerebral Infarction as well as Sleep-disordered Breathing

Objective:To investigate the depressive status and its effects on the quality of life in patients with cerebral infarction as well as sleep-disordered breathing during sub-acute period. Methods:156 cerebral infarction patients targeted to the inclusion criteria were divided into 98 with sleep-disordered breathing and 58 without sleep-disordered breathing. The depressive status and quality of life were evaluated with Hamilton Depressive scale (HAMD) and Stroke Impact Scale (SIS) 2 weeks after stroke onset. Results:Patients with sleep-disordered breathing showed higher HAMD overall score and factor scores of anxiety,cognitive impairment,retardation,sleep problem and hopelessness (P0.05,0.01). Patients with sleep-disordered breathing had lower scores in the SIS dimensions of memory/thinking,social activity,mobile ability (P0.05,0.01). The scores of memory/thinking,activities of daily living,social activity,hand function and mobile ability were related to the HAMD overall score and factor scores of anxiety/somatization,cognitive impairment,retardation and despair (P0.05,0.01,0.001). Conclusion:Patients with cerebral infarction as well as sleep-disordered breathing have worse depressive status and quality of life than those without sleep-disordered breathing during sub-acute period. Depression is closely correlated to SIS quality of life.