2012•Journal of Functional BiomaterialsOpen access
Preparation and performance study of chitosan microspheres loaded solid dispersion
Xiguang Chen
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Abstract
In the present work,four kinds of chitosan-based microspheres with different molecular weight of chitosan were prepared by emulsion-chemical crosslinking method.The characterizations of the microspheres were investigated regarding mean particle size,swelling ratio,drug-loading efficiency,encapsulation efficiency and performance of slow-release.The results indicated that the microspheres prepared with 240kDa of chitosan had higher drug-loading efficiency,higher encapsulation efficiency and more slowly released speed than the other microspheres.The chitosan-solid dispersion microspheres prepared with 240kDa of chitosan increased the solubility of ibuprofen and decreased the speed of drug release.The results revealed that the chitosan-solid dispersion microspheres had potential applications in drug release systems.