CLINICAL SIGNIFICANCE OF COAGULATION FUNCTION CHANGES IN PATIENTS WITH SYSTEMIC INFLAMMATORY RESPONSE SYNDROME

Objective To investigate the changes of coagulation function,and their relationship with the severity and prognosis of patients with systemic inflammatory response syndrome(SIRS). Methods One hundred patients complicated by SIRS were randomly selected.One day after the patients were enrolled in ICU,platelet count and antithrombin Ⅲ were measured.Plasma D-dimer was determined by immune turbidimetry.The relationship between SIRS score and coagulation disorders,and the difference of coagulation factors between the survival and death groups were analyzed. Results As SIRS score increased,the platelet count and antithrombin Ⅲ activity of SIRS patients decreased,and the level of D-dimer significantly increased(t=6.79-16.37,P0.01).The platelet count in the survival group was significantly higher than that of the death group(t=4.58,P0.01).The antithrombin Ⅲ activity in the survival group was significantly higher than that of the death group(t=6.21,P0.01).Plasma D-dimer in the survival group was significantly lower than that of the death group(t=8.75,P0.01). Conclusion Patients with SIRS has an activation of coagulation function,which induces complex systemic inflammation-coagulation reaction.The severer the inflammation is,the more obvious the abnormal coagulation activation,and the poorer the prognosis will be.