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2007•Chinese Journal of New Drugs and Clinical RemediesRequires access

Effects of baicalin on chemotaxis of monocytes THP-1 cell

Lili Ji, Sheng Yu-chen

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Abstract

AIM:To observe the effects of baicalin on the chemotaxis of monocytes THP-1 cells. METHODS:FACS analysis was used to test the expression of chemokine CXCR4 and CCR1 receptors,and the lymphocytes chemotaxis analysis was used to observe the chemotaxis of monocytes THP-1 cells.RESULTS: Chemokine receptors CXCR4 and CCR1 expressed on the THP-1 cell surface.100μmol-L~(-1) and 30μmol·L~(-1) baicalin inhibited the chemokine SDF-1α-induced chemotaxis of monocytes THP-1 cells significantly,but had no effect on the chemokine RANTES-induced chemotaxis and serum-induced chemotaxis.Baicalin itself has no effect on THP-1 migration.CONCLUSION:Baicalin can inhibite the chemokine SDF-1α/CXCR4 induced chemotaxis of monocytes THP-1 cells.

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What this paper is about

AIM:To observe the effects of baicalin on the chemotaxis of monocytes THP-1 cells. METHODS:FACS analysis was used to test the expression of chemokine CXCR4 and CCR1 receptors,and the lymphocytes chemotaxis analysis was used to observe the chemotaxis of monocytes THP-1 cells.RESULTS: Chemokine receptors CXCR4 and CCR1 expressed on the THP-1 cell surface.100μmol-L~(-1) and 30μmol·L~(-1) baicalin inhibited the chemokine SDF-1α-induced chemotaxis of monocytes THP-1 cells significantly,but had no effect on the chemokine RANTES-induced chemotaxis and serum-induced chemotaxis.Baicalin itself has no effect on THP-1 migration.CONCLUSION:Baicalin can inhibite the chemokine SDF-1α/CXCR4 induced chemotaxis of monocytes THP-1 cells.

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Available abstract

AIM:To observe the effects of baicalin on the chemotaxis of monocytes THP-1 cells. METHODS:FACS analysis was used to test the expression of chemokine CXCR4 and CCR1 receptors,and the lymphocytes chemotaxis analysis was used to observe the chemotaxis of monocytes THP-1 cells.RESULTS: Chemokine receptors CXCR4 and CCR1 expressed on the THP-1 cell surface.100μmol-L~(-1) and 30μmol·L~(-1) baicalin inhibited the chemokine SDF-1α-induced chemotaxis of monocytes THP-1 cells significantly,but had no effect on the chemokine RANTES-induced chemotaxis and serum-induced chemotaxis.Baicalin itself has no effect on THP-1 migration.CONCLUSION:Baicalin can inhibite the chemokine SDF-1α/CXCR4 induced chemotaxis of monocytes THP-1 cells.

Key concepts: Chemotaxis, Chemokine receptor, Baicalin, Chemokine, THP1 cell line, CC chemokine receptors, Cell biology, CXCL14

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