Doppler flow waveform of fetal ductus venosus in early screening for fetal malformation

Objective:To investigate the clinical significance of Doppler flow waveform of ductus venosus(DV) in screening of fetal malformation..Methods:Ductus venosus blood flow velocity wave forms and nuchal translucency thickness of 3 586 fetus with gestation of 11~14 weeks were measured with ultrasonography,who were followed-up till birth.Results:29 abnormal Doppler flow waveform of the DV were obtained.11 fetal karyotypes were detected,and 6 fetal karyotypes were abnormal.By following-up ultrasonographic screening,13 abnormalities were identified.There were 10 congenital heart defects of 13 abnormalities,2 fetuses were died at uterus..Conclusion:Doppler ultrasonographic detection of DV blood flow at 11~14 weeks will be useful as a new prospective technique in screening of fetal abnormalities,especially congenital heart defects.