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Improvement of the Synthesis Method of 4-hydroxy-3-methoxyphenylacetonitrile

Lai Yi-tian

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Abstract

[Objective] To improve the synthesis process of 4-hydroxy-3-methoxy phenylacetonitrile.[Method] By using KF/Al2O3 as dehydrant,the 4-hydroxy-3-methoxyphenylacetonitrile was synthesized from the raw material of vanillin via multiple steps.[Result] Optimal reaction conditions were 1.0∶1.2 of 3-methoxy-4-acetoxyphenylacetonitrile:hydroxylamine hydrochloride(molar ratio),100 ℃ of temperature,7.5 h of time,and 1.0∶1.5 of KF∶Al2O3(quality ratio).The structure of these compounds has been determined by IR spectra,elemental analysis and 1H NMR.[Conclusion] The reported method is simple and economical.

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What this paper is about

[Objective] To improve the synthesis process of 4-hydroxy-3-methoxy phenylacetonitrile.[Method] By using KF/Al2O3 as dehydrant,the 4-hydroxy-3-methoxyphenylacetonitrile was synthesized from the raw material of vanillin via multiple steps.[Result] Optimal reaction conditions were 1.0∶1.2 of 3-methoxy-4-acetoxyphenylacetonitrile:hydroxylamine hydrochloride(molar ratio),100 ℃ of temperature,7.5 h of time,and 1.0∶1.5 of KF∶Al2O3(quality ratio).The structure of these compounds has been determined by IR spectra,elemental analysis and 1H NMR.[Conclusion] The reported method is simple and economical.

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Available abstract

[Objective] To improve the synthesis process of 4-hydroxy-3-methoxy phenylacetonitrile.[Method] By using KF/Al2O3 as dehydrant,the 4-hydroxy-3-methoxyphenylacetonitrile was synthesized from the raw material of vanillin via multiple steps.[Result] Optimal reaction conditions were 1.0∶1.2 of 3-methoxy-4-acetoxyphenylacetonitrile:hydroxylamine hydrochloride(molar ratio),100 ℃ of temperature,7.5 h of time,and 1.0∶1.5 of KF∶Al2O3(quality ratio).The structure of these compounds has been determined by IR spectra,elemental analysis and 1H NMR.[Conclusion] The reported method is simple and economical.

Key concepts: Hydroxylamine Hydrochloride, Raw material, Molar ratio, Vanillin, Elemental analysis, Proton NMR, Chemistry, Hydroxylamine

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