The Characteristics and Influencing Factors of Parkinson's Disease with Mild Cognitive Impairment

Objective:To investigate the frequency of mild cognitive impairment in patients with Parkinson's disease(PD) and healthy controls over 55 years of age without dementia and to analyze the characteristics and influencing factors of PD with mild cognitive impairment. Methods:One hundred and twelve PD patients having a normal age and education adjusted MMSE score were included in the further study of MoCA testing. Patients with MoCA score no less than 26 were selected into normal control PD-NC group,and patients with MoCA score less than 26 into mild cognitive impaired PD-MCI group. The frequency and influencing factors of PD-MCI were statistically analyzed. One hundred and fifteen healthy subjects over the age of 55 without dementia were selected as control group,which divided into normal control C-NC group and mild cognitive impaired C-MCI group by MoCA testing.Scores of MoCA subtests were used in PD-MCI group and C-MCI group to compare the difference and characterize of cognitive changes. Results:The incidence of MCI in PD-MCI group was 55.4%(62/112) and 27.8%(32/115) in C-MCI group,with a significant difference between these 2 groups(χ2=17.73,P0.05). PD-MCI patients had lower scores in subtests of MoCA in visuospatia1, executive,attention and orientation compared with C-MCI patients(P0.05). Univariate and logistic regression analysis revealed that a high frequency of PD-MCI occurred in patients with high UPDRS Ⅲscore,H-Y stage,and HAMD score. Conclusion:MCI is common in patients with PD,and the main cognitive deficits involve visuospatial,executive,attention, and orientation,which is associated with severity of motor disturbances and depression.