Effects of limited fluid resuscitation on inflammatory factor in patients with trauma hemorrhage shock

【Objective】To investigate the effects of limited fluid resuscitation on inflammatory factor in patients with trauma hemorrhage shock. 【Methods】220 patients with trauma hemorrhagic shock were randomly divided into limited fluid resuscitation group (n =110) and large quantity fluid rapid resuscitation group (n =110), additionally, 30 healthy volunteers as healthy volunteers group (n =30). The levels of TNF-α, IL-1β, IL-6 and IL-10 were assessed with enzyme-linked immunosorbent assay (ELISA). 【Results】Compared with the healthy volunteers group, the levels of TNF-α, IL-1β, IL-6 and IL-10 were significantly increased in limited fluid resuscitation group and large quantity fluid rapid resuscitation group. The levels of TNF-α, IL-1β, IL-6 and IL-10 were all increased progressively with time passed in limited fluid resuscitation group and large quantity fluid rapid resuscitation group, but the levels of TNF-α, IL-1β, IL-6 and IL-10 in large quantity fluid rapid resuscitation group were markedly higher than limited fluid resuscitation group at the time point of 120 min and 240 min after in-hospital. 【Conclusions】Limited fluid resuscitation can inhibit the over-release of inflammatory factor in patients with trauma hemorrhage shock effectively. It can hold-back the proceeding of SIRS at some extent.