Effect of uncommon risk factors on cardiac remodeling and dysfunction in patients with acute myocardial infarction

Objective To evaluate the effect of risk factors and the number of coronary branch with stenosis on leftventricular remodeling and systolic function in patients with acute myocardial infarction (AMI). Methods According totypical clinical symptom, cTnT, cardiac enzyme and ECG, 180 patients with AMI were involved in this study. The num-ber of coronary branch with stenosis was quantified by coronary angiography. Cardiac parameters including end- dias-tolic interventricular septum thickness (IVSd), end- diastolic left ventricular internal diameter (LVd), left ventricular mass(LM) and left ventricular ejection fraction (LVEF) were measured by echocardiography. The effluence of t the number ofcoronary branch with stenosis, blood pressure, blood lipids, and glucose on LVEF and LVd was analyzed. Results Thenumber of coronary branch with stenosis and systolic blood pressure after AMI were related negatively to LVEF, whilethere were no significant relationship between other facts and LVEF. LVEF was significantly decreased, while LVd andLM were remarkably increased in patients with hypertension before AMI, compared with patients without hypertension(P0.001). Conclusion Multiple vessel stenosis and systolic blood pressure mainly affected LVEF after AMI. An-tecedent hypertension might be one of the reasons leading to cardiac remodeling and dysfunction. Therefore primary pre-vention of coronary heart disease is important for protecting heart from remodeling and dysfunction.