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Effect of nitric oxide on inhibition of VSMC proliferation induced by lipopolysaccharide

Ying Li

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Abstract

To investigate the effects of LPS on the proliferation DNA synthesis NO production and iNOS expression of VSMC MTT method 3 H-TdR incorporation spectrophotometer measurement and immunohistochem- istry method were used The results suggested that LPS could inhibit the proliferation and DNA synthesis of VSMC which was probably realized by the iNOS-NO-cGMP pathway

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What this paper is about

To investigate the effects of LPS on the proliferation DNA synthesis NO production and iNOS expression of VSMC MTT method 3 H-TdR incorporation spectrophotometer measurement and immunohistochem- istry method were used The results suggested that LPS could inhibit the proliferation and DNA synthesis of VSMC which was probably realized by the iNOS-NO-cGMP pathway

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Available abstract

To investigate the effects of LPS on the proliferation DNA synthesis NO production and iNOS expression of VSMC MTT method 3 H-TdR incorporation spectrophotometer measurement and immunohistochem- istry method were used The results suggested that LPS could inhibit the proliferation and DNA synthesis of VSMC which was probably realized by the iNOS-NO-cGMP pathway

Key concepts: Nitric oxide, DNA synthesis, Lipopolysaccharide, Chemistry, Cell growth, MTT assay, DNA, Molecular biology

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