Curative effectivenss of lamivudine combined with thymosin α_1 in the treatment of chronic hepatitis B

Objective To observe the curative effectiveness of thymosin α1 combined with lamivudine in the treatment of chronic hepatitis B. Methods Seventy patients with chronic hepatitis B were randomly divided into treatment group (35 cases) and control group (35 cases). Lamivudine was administrated orally with 100 mg per day for 12 months,as well as other treatments in control group. Treatment group was given with hypodermic injection of thymosin-α1,twice a week for 6 months besides lamivudine treatment. Results On the 6th,12th month after treatment,and 6th month after drug withdrawal,there was no significant difference in the recovery rate of ALT and the clearance rate of HBV-DNA between two,but the clearance rate of HBeAg and HBeAg/HBeAb was significantly different between two groups on the 12th month after tretments and 6th month after drug withdrawal. Conclusion The treatment of thymosin α1 combined with lamivudine for chronic hepatitis B can improve the outcomes.