2013•Journal of Clinical CardiologyRequires access

Effects of Rho/Rho kinase signaling on ventricular remodeling induced by isoprenaline in rats

Jin Wang

Abstract

Objective:To investigate the effect of RhoA/Rho kinase signaling pathway on cardiac fibrosis induced by isoproterenol(ISO)in rats.Method:Twenty four SD rats were randomly divided into control group,ISO model group and Fasudil(Fas)group.After 6 weeks,the ratio of heart weight to body weight(HW/BW,HWI)was determined.Transforming growth factor β1(TGF-β1)protein in myocardium was detected by immunohistochemistry(IHC)staining.RhoA and Rho kinase mRNA were tested by RT-PCR.Result:The HWI,protein of TGF-β1,RhoA and Rho kinase mRNA were lower in Fas group than in ISO model group(P0.01).Conclusion:Rho/Rho kinase signaling pathway may play an important role in myocardial fibrosis induced by ISO,and Fas,as Rho kinase inhibitor,can inhibit RhoA/Rho kinase signaling pathway and down-regulate TGF-β1 expression.

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Key concepts: RHOA, Fasudil, Rho-associated protein kinase, Medicine, Isoprenaline, Rho kinase inhibitor, Protein kinase A, Kinase