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2012•Strait Pharmaceutical JournalRequires access

The effect of adipokines expression on insulin resistance and metabolic syndrome

Baolin Liu

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Abstract

Adipokines are cytokines secreted by adipose tissue,such as tumor necrosis factor(TNF)-alpha,interleukin(IL)-6,leptin and adiponectin,etc.Some of these adipokines,including TNF-α,IL-6 and resistin take part in the initiation of insulin resistance and contribute to metabolic syndrome by stimulation of inflammation.In view of the involvement of dysregualtion of adipokine expression in the pathophysiology of insulin resistance implicated in obesity,diabetes and metabolic syndrome.This paper reviewed the relationship between adipokines and insulin resistance,trying to provide clues of the mechanism and treatment strategies to obesity,diabetes and metabolic syndrome.

About this research paper

What this paper is about

Adipokines are cytokines secreted by adipose tissue,such as tumor necrosis factor(TNF)-alpha,interleukin(IL)-6,leptin and adiponectin,etc.Some of these adipokines,including TNF-α,IL-6 and resistin take part in the initiation of insulin resistance and contribute to metabolic syndrome by stimulation of inflammation.In view of the involvement of dysregualtion of adipokine expression in the pathophysiology of insulin resistance implicated in obesity,diabetes and metabolic syndrome.This paper reviewed the relationship between adipokines and insulin resistance,trying to provide clues of the mechanism and treatment strategies to obesity,diabetes and metabolic syndrome.

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Available abstract

Adipokines are cytokines secreted by adipose tissue,such as tumor necrosis factor(TNF)-alpha,interleukin(IL)-6,leptin and adiponectin,etc.Some of these adipokines,including TNF-α,IL-6 and resistin take part in the initiation of insulin resistance and contribute to metabolic syndrome by stimulation of inflammation.In view of the involvement of dysregualtion of adipokine expression in the pathophysiology of insulin resistance implicated in obesity,diabetes and metabolic syndrome.This paper reviewed the relationship between adipokines and insulin resistance,trying to provide clues of the mechanism and treatment strategies to obesity,diabetes and metabolic syndrome.

Key concepts: Adipokine, Resistin, Adiponectin, Insulin resistance, Metabolic syndrome, Endocrinology, Internal medicine, Adipose tissue

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