Advance in research of non-monoamine-targeted antidepressants

Most currently available antidepressants in clinic are based upon monoamine targets.The targets include 5-HT receptor,NE receptor and DA receptor.However,these antidepressants are far from fulfilling our expectations in terms of efficacy,onset of action and side effects.The increasing understanding of the molecular mechanisms of depression shows that many non-monoamine targets are also involved in depression too.The antidepressants of non-monoamine targets have become the hot research of antidepressants,and there are increasing reports of these antidepressants.The non-monoamine-targeted antidepressants exhibit high activity in receptor binding and animal models of depression;some of them are under clinical trials.The clinical trials indicate that several non-monoamine-targeted antidepressants have a faster onset of antidepressant action.In the article,we reviewed the advance in the research of non-monoamine-targeted antidepressants.