The relativity between gastroesophageal reflux disease with or without esophageal injury and esophageal motility and acid reflux

Objective To study the relation of esophageal motility and acid reflux between gastroesophageal reflux disease(GERD) patients with and without esophageal injury. Methods 75 cases of patients with gastroesophageal reflux from January 2012 to August 2013 were conducted esophageal-gastric-duodenal endoscopy examination and followed with high-resolution esophageal manometry, and detected the changes of esophageal pH postprandial,. The differences of esophageal motility and acid reflux time between esophageal injury group and without esophageal injury group were compared, and the changes of esophageal motility indexes between non acid reflux and acid reflux group were compared whether there is statistical significance. Results There was no significant difference in baseline value of lower esophageal sphincter pressure, remained lower esophageal sphincter pressure, speed of the esophageal peristalsis, the time of esophageal pH 4 and DeMeester score between groups with and without esophageal injury(all P 0.05), esophageal contraction amplitude of group with without esophageal injury was higher than that of esophageal injury group, which had significant difference(P0.05). There was no significant difference in baseline value of ower esophageal sphincter pressure, remained LES pressure, speed of the esophageal peristalsis between acid reflux group and non acid reflux group(all P0.05), the esophageal contraction amplitude of acid reflux group was lower than that of non acid reflux group, which had significant difference(P0.05). The difference was not statistically significant. Conclusions There was no significant correlation between the lower esophageal sphincter pressure and esophageal acid reflux with esophageal injury in GERD patients. But esophageal peristalie contraction may be associated with esophageal injury and acid reflux.