Clinical Observation of Therapeutic Efficiency of Insulin Glargine Combined with Oral Hypoglycemic Agents in Elderly Patients with Type 2 Diabetes

Objective To evaluate the clinical observation of therapeutic efficiency and safty of insulin glargine combined with oral hypoglycemic agents in elderly patients with type 2 diabetes.Methods Fifty six elderly patients with type 2 diabetes and poorly glycemic control by oral medication were randomly divided into two groups:insulin glargine(+) group and isophane insulin(+) group.FBG,P2hBG,HbA1c and BMI in each group were measured before and after 24 weeks of treatment,and the adverse effect were also recorded.Results HbA1c,FBG and P2hBG of the two groups were declined obviously after 24 weeks of treatment,and the therapeutic equivalence between the two groups.No significant change of BMI in the two groups.But the incidence of severe hypoglycemia in the insulin glargine group was lower than that in the isophane insulin group.Conclusion The therapeutic equivalence of insulin glargine and isophane insulin in decreasing the blood sugar was observed,but the security in insulin glargine group was higher than that in the low protamine zinc insulin group.