Effects of different doses sufentanil on hemodynamics in elderly patients induction

Objective To determine the effect of different doses sufentanil on hemodynamics in elderly patients during endotracheal intubation.Methods One hundred and twenty patients aged 65 to 79 years old undergoing selective surgery were devided randomly into six groups with 20 cases each.The patients were induced with midazolam 0.08 mg/kg,propofol mg/kg,sufentanil 0.2μg/kg(groupⅠ),0.3μg/kg(groupⅡ),0.4μg/kg(group Ⅲ),0.5μg/kg(group Ⅳ),0.6μg/kg(group Ⅴ),0.7μg/kg(group Ⅵ) and vecuronium 0.1 mg/kg.The values of SBP,DBP and HR were recorded before anesthesia(T0),before intubation(T1),the moment of intubation(T2),1min(T3),3min(T4) and 5min(T5) after intubation.Results Compared with group Ⅲ,SBP,DBP and HR were no significant differences at each time point in group Ⅳ(P0.05).The incidence of hypertension and tachycardia in group Ⅰand Ⅱwere higher at T2,T3,T4 and T5 than those in group Ⅲ and Ⅳ(P0.05).The incidence of hypotension and bradycardia in group Ⅴ and Ⅵwere higher at T1,T2,T3,T4 and T5 than those in group Ⅲ and Ⅳ(P0.05).Conclusion The hemodynamic was more stable in elderly patients induced with sufentanil 0.4～0.5μg/kg.