Clinical study of non-small cell lung cancer using three-dimensional conformal radiotherapy

Objective To investigate the therapeutic effects of three dimensional conformal radiotherapy (3 DCRT) and 3DCRT combined with chemotherapy for non-small cell lung cancer(NSCLC).Methods 63 patients who were treated with radiotherapy alone (RT group,27cases) or radiotherapy plus chemotherapy (CRT group,36 cases)were entered into the database for study.The median total dose was 60 Gy.The GTV dose start dose escalation after the CTV irradiated 60 Gy (2 Gy/times,1times/day,and 5 days/week).The boost fractions were 3-11 times (2 Gy /fraction) and did not conduct regional lymph node preventive irradiation.36 cases combined chemotherapy,chemotherapy with platinum-based and major programs including the NP program and the TP program.Results The complete remission was 27.0(17/63) and partial remission was 65.1%(41/63).The response rate was 92.1%.1 and 2 year overall survival rates were 57.1%,38.1% respectively.The median survival rate of the entire group was 14 months.The difference of the groups was statistically significant (x 2 =7.567,P= 0.006).Univariate and multivariate analysis did not show adverse factors.Conclusion 3DCRT joint chemotherapy is safe and effective.Both in combination can improve the clinical efficiency of NSCLC.Compared with radiotherapy alone there was a better sort-term effect,no significant increase on the basis of radiation side effects from the radiotherapy and chemotherapy group and 1 and 2 year prolonged survival rates.Radiation injury can be tolerated.The radiation dose has room for improvement and need further study.