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2010•Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhiRequires access

Effect of paclitaxel on proliferation and apoptosis of human choriocarcinoma cell line JEG-3

Cen Li

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Abstract

【Objective】To explore apoptosis and cell cycle distribution of human choriocarcinoma cell line JEG-3 treated by paclitaxel. 【Methods】The effect of paclitaxel on the proliferation of human choriocarcinoma cell line JEG-3 was evaluated by MTT growth assay. The rate of apoptosis and the cell cycle distribution were analyzed by flow cytometry. 【Results】Paclitaxel could inhibit the proliferation of cell line JEG-3. The inhibition effects were concentration and time dependent. Paclitaxel could affect the apoptosis of cells and the cell cycle distribution. The rate of apoptosis and the percentage of G2/M cells increased as the concentration of paclitaxel increased and the action time was prolonged.【Conclusion】Paclitaxel can induce apoptosis of human choriocarcinoma cell line JEG-3.

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What this paper is about

【Objective】To explore apoptosis and cell cycle distribution of human choriocarcinoma cell line JEG-3 treated by paclitaxel. 【Methods】The effect of paclitaxel on the proliferation of human choriocarcinoma cell line JEG-3 was evaluated by MTT growth assay. The rate of apoptosis and the cell cycle distribution were analyzed by flow cytometry. 【Results】Paclitaxel could inhibit the proliferation of cell line JEG-3. The inhibition effects were concentration and time dependent. Paclitaxel could affect the apoptosis of cells and the cell cycle distribution. The rate of apoptosis and the percentage of G2/M cells increased as the concentration of paclitaxel increased and the action time was prolonged.【Conclusion】Paclitaxel can induce apoptosis of human choriocarcinoma cell line JEG-3.

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Available abstract

【Objective】To explore apoptosis and cell cycle distribution of human choriocarcinoma cell line JEG-3 treated by paclitaxel. 【Methods】The effect of paclitaxel on the proliferation of human choriocarcinoma cell line JEG-3 was evaluated by MTT growth assay. The rate of apoptosis and the cell cycle distribution were analyzed by flow cytometry. 【Results】Paclitaxel could inhibit the proliferation of cell line JEG-3. The inhibition effects were concentration and time dependent. Paclitaxel could affect the apoptosis of cells and the cell cycle distribution. The rate of apoptosis and the percentage of G2/M cells increased as the concentration of paclitaxel increased and the action time was prolonged.【Conclusion】Paclitaxel can induce apoptosis of human choriocarcinoma cell line JEG-3.

Key concepts: Paclitaxel, Apoptosis, Choriocarcinoma, Cell cycle, Flow cytometry, Cell growth, Cell culture, Chemistry

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Effect of paclitaxel on proliferation and apoptosis of human choriocarcinoma cell line JEG-3 — Research Paper | ScholarLens