Randomized controlled multicentric clinical trial of domestic and imported cefepime in the treatment of acute urinary infections

Objective To compare the clinical and bacterial efficacy and safety of domestic and imported cefepime in the treatment of moderate to severe urinary tract infection. Methods A randomized controlled clinical trial was conducted in the treatment of patients with urinary tract infection. One hundred and twenty seven patients were enrolled in the trial, 5 patients were withdrawn. There were 61 cases in domestic group and 61 cases in imported group assessable respectively. Both drugs were given intravenously 2 g for urinary tract infection respectively within 30 to 60 minutes by infusion,twice daily. The duration of treatment was 7 to14 days in both groups. Results The overall clinical efficacy rate of domestic and imported group was 98.36% and 96.72%, the bacterial eradication rate both was 100%, and the incidence of adverse reaction was 6.45% and 10.77% respectively. The difference was no significant between two groups. Conclusion Domestic cefepime is as effective and safe as imported one in the treatment of moderate and severe urinary tract infection.