Study of Microvessel Density and Vascular Endothelial Growth Factor in Non-small Cell Lung Cancer

Objective To investigate the correlation between the microvessel density(MVD) and expression level of vascular endothelial growth factor(VEGF) and biological behavior of non-small cell lung cancer(NSCLC) and its prognosis. Methods MVD and VEGF expression in 56 cases of NSCLC and 16 cases of nomal lung tissues was tested with immunohistochemistry methods. Results (1)significant differences in MVD and VEGF expression were found between NSCLC and nomal lung tissues (P0.05),lung cancer MVD increased with the increase of the VEGF expression,they had positive relation.(2)MVD and VEGF expression in lung adenocarcinoma was higher than that in squamosumcarcinoma (P0.05),they increased with the lymphnode metastasis and advancing of TNM Stage (P0.05).(3)Between the survival time in the group less than 2 years and the group more than 2 years, both MVD and VEGF expression had significant difference(P0.05).Conclusion MVD and VEGF are closely related to the occurrence,development and metastasis of NSCLC, they can be used as a major judgement parameter for biological behavior and prognosis of NSCLC.