Effect of Polymorphisms of CYP2C9 and VKORC1 on Warfarin Dosage

Warfarin is widely used as an oral anticoagulant in clinical practice.It has a narrow therapeutic range but a large individual variation.Especially,it leads to serious bleeding complications easily in early treatment.The rational and safe use of warfarin has been becoming a key problem in clinical practice.The efficacy of warfarin is affected by many factors,and the genetic polymorphism of hereditary factors is prominent.In recent years,with the development of pharmacogenomics,the studies show that the genetic polymorphisms of related genes in pharmacokinetics and pharmacodynamics result in interindividual variation in warfarin.We review the effects of genetic polymorphisms,such as CYP2C9 and VKORC1,on drug response and therapeutic efficacy of warfarin.