Effect of sevoflurane and propofol on stress response in patients undergoing open heart surgery

Objective To investigate the effect of sevoflurane anesthesia and propofol anesthesia on endocrine stress response in patients undergoing open heart surgery during cardiopulmonary bypass(CPB).Methods Forty ASA Ⅱ or Ⅲ patients were randomly allocated to one of two groups(n=20):sevoflurane anesthesia group(group S) and propofol anesthesia group(group P).MAP,HR,BIS,plasma concentration of adrenocorticotropic hormone(ACTH) and cortisol(Cor),were recorded before induction(T0),at 5 min after intubation(T1),at 30 min after the initiation of CPB(T2),at the end of CPB(T3) and operation(T4).Results Compared with T0,MAP,HR,BIS,and levels of ACTH and Cor,decreased significantly at T1(P 0.05) while ACTH and Cor increased significantly at T2-T4(P 0.01) in both groups.MAP,BIS,and levels of ACTH and Cor,in group P were significantly higher than those in group S at T2-T3(P 0.05).Conclusion Sevoflurane inhalation anesthesia can more effectively inhibit the stress response in patients undergoing open heart operation during CPB than propofol anesthesia.