Observation of therapeutic effect on hypertrophic scars and keloid after treatment with intralesinal triamcinolone acetonide mixed with 5-fluorourcil

Objective To evaluate the effects of intralesinal triamcinolone acetonide mixed with 5-fluorourcil on hypertrophic scars. Methods 58 cases patients with hypertrophic scar and keloid were randomly divided into the treatment group and the control group.The hypertrophic scars and keloid were injected intralesionally with triamcinolone acetonide mixed with 5-fluorouracil(treatment group), triamcinolone acetonide(control group). The curative rate and effective rate of those two groups were compared. Results All cases were followed up from 12~18 months. The curative rate was 75.86 %(treatment group )and 48.28 %(control group ); the effective rate was 93.1 %(treatment group )and 72.41 %(control group ). The different of curative rate and effective rate between treatment group and control group is significant. Conclusion The therapeutic effect on hypertrophic scars and keloid after treatment with intralesinal triamcinolone acetonide mixed with 5-fluorourcil appears to be both effective and safe.