The Effect of Helicid on MWT and TWL in Rat Model with Chronic Compression Injury of Sciatic Nerve

Objective: To observe the effect of helicid on mechanical withdrawal threshold(MWT) and thermal withdrawal latency(TWL) in rat model with chronic compression injury of sciatic nerve as well as to explore its regulation during the development of neuropathic pain.Method: Thirty-two rats were randomly divided into four groups(n=8): sham group(sham operation),CCI group(group of CCI models),low dose group of helicid(H1) and high dose group of helicid(H2).Four groups were administered with drugs intragastrically at the day before operation and the tenth day after operation,once each day.MWT and TWL of hind legs were tested for ten consecutive days.Result: At the ninth day after CCI surgery sham group,CCI group,H1group and H2 group were compared with basic indexes of MWT and TWL before operation,sham group showed no difference(P0.05),CCI group,H1group and H2 group demonstrated differences(P0.05),models with CCI were established successfully at the ninth day after CCI operation.During the first day to tenth day after medication,H1 group and H2 group were compared with CCI group respectively,indicating that MWT and TWL increased significantly(P0.05) as well as H2 group was higher than H1 group.Conclusion: Oral helicid can raise MWT of CCI rat dose-dependently,delay TWL and postpone the development of neuropathic pain of rat.