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Effects of neural stem cells modified by nephroblastoma overexpressed gene transplantation on the function recovery in rats with spinal cord injury

Li Cheng

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Abstract

Objective To observe the effects of neural stem cells(NSCs) modified by nephroblastoma overexpressed gene(NOV) on function recovery in rats with spinal cord injury. Methods Forty Wistar rats were randomly divided into four groups: control group(A), injury group(B), NSCs group(C) and NOV group(D). Two months after operation, the function recovery of spinal cord was determined using BBB scores and cortical somatosensory evoked potential(CSEP). Results ① Assessed by BBB scores, function recovery was found in groups of B, C and D, but it did not reach normal level. There was significant difference between group B and groups C and D(group D superior to group C). ② CSEP in group B disappeared, and the latency time of CSEP in groups C and D was prolonged, but it was shorter in group D than that in group C. Conclusion NSCs modified by NOV gene transplantation could improve partial recovery of motor function and conduction function of injured spinal cord in rats.

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Objective To observe the effects of neural stem cells(NSCs) modified by nephroblastoma overexpressed gene(NOV) on function recovery in rats with spinal cord injury. Methods Forty Wistar rats were randomly divided into four groups: control group(A), injury group(B), NSCs group(C) and NOV group(D). Two months after operation, the function recovery of spinal cord was determined using BBB scores and cortical somatosensory evoked potential(CSEP). Results ① Assessed by BBB scores, function recovery was found in groups of B, C and D, but it did not reach normal level. There was significant difference between group B and groups C and D(group D superior to group C). ② CSEP in group B disappeared, and the latency time of CSEP in groups C and D was prolonged, but it was shorter in group D than that in group C. Conclusion NSCs modified by NOV gene transplantation could improve partial recovery of motor function and conduction function of injured spinal cord in rats.

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Available abstract

Objective To observe the effects of neural stem cells(NSCs) modified by nephroblastoma overexpressed gene(NOV) on function recovery in rats with spinal cord injury. Methods Forty Wistar rats were randomly divided into four groups: control group(A), injury group(B), NSCs group(C) and NOV group(D). Two months after operation, the function recovery of spinal cord was determined using BBB scores and cortical somatosensory evoked potential(CSEP). Results ① Assessed by BBB scores, function recovery was found in groups of B, C and D, but it did not reach normal level. There was significant difference between group B and groups C and D(group D superior to group C). ② CSEP in group B disappeared, and the latency time of CSEP in groups C and D was prolonged, but it was shorter in group D than that in group C. Conclusion NSCs modified by NOV gene transplantation could improve partial recovery of motor function and conduction function of injured spinal cord in rats.

Key concepts: Spinal cord, Spinal cord injury, Transplantation, Neural stem cell, Somatosensory evoked potential, Somatosensory system, Medicine, Group A

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Effects of neural stem cells modified by nephroblastoma overexpressed gene transplantation on the function recovery in rats with spinal cord injury — Research Paper | ScholarLens