2015•Pharmacy TodayRequires access

Application of Fiber-Optic Dissolution Tester for Dissolution Test in A Factory

Zheng Xianqian

Abstract

OBJECTIVE To inspect the feasibility of the dissolution test using fiber-optic dissolution tester for oral solid preparation in a factory. METHODS Detect the dissolution test with fiber-optic dissolution tester,while sampling,filtering and diluting were detected by uv-vis spectrophotometer,then the single grain difference and the average difference between the two results were calculated. RESULTS For the dissolution of 12 varieties in the factory,the maximum difference of single grain was 4%,while3% on average. CONCLUSION The fiber-optic dissolution tester can be used in dissolution test for 12 varieties in the factory.

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Key concepts: Dissolution, Dissolution testing, Materials science, Significant difference, Factory (object-oriented programming), Fiber, Optical fiber, Optics