Pharmacokinetics of Mycophenolate Mofetil Administered in Multiple Oral Dose in Renal Transplantation Recipients

Objective To study pharmacokinetics of mycophenolic acid (MPA) after Mycophenolate mofetil (MMF) was administered in mulpital oral dose in renal transplantation recipients.Methods 24 first renal allograft recipients were divided into 2 groups. All received a triple immunosuppressive regimen of MMF,cyclosporine (CsA) and corticosteroids. 9 samples of serum were drawn at the day 7 and day 14 after transplantation. MPA concentration was determined by HPLC and MPA pharmacokinetic parameters were calculated. Results The main pharmacokinetic parameters of MPA at the day 7 and day 14 after transplantation were as follows: Cmax were (12.3±5.7) and (12.3±5.4)μg/ml (P0.05);C0 were (0.7±0.5) and (1.8±1.0)μg/ml (P0.05);Tmax were (1.5±0.9) and (1.3±0.6) h (P0.05);AUC0-12h were (27.0±10.1) and (39.8±16.4) μg·h/ml (P0.05);MRT0-12h were (3.2±0.8) and (4.0±0.6)h (P0.05). Conclusion: The accumulation for MPA after MMF administered in multiple oral dose in renal transplantation recipients was detected. MPA plasma concentration should be monitored in clinical practice.