THE EXPRESSION AND SIGNIFICANCE OF SYNAPTOPHYSIN IN HIPPOCAMPAL FORMATION IN ACUTE ANIMAL MODEL OF EPILEPSY

[Objective]To study the changes in expression of synaptophysin(SYN) in hippocampal formation after coriaria lactone induced acute animal model of epilepsy,and the relationship between synaptic transmission and the mechanism of status epilepticus.[Methods]30 adult male Sprague-Dawley rats were divided randomly into model group and control group. The rats were injected into lateral ventricle with coriaria lactone(50 μg/kg). The sections of the brains were processed by immunochemistry with antibodies against SYN.[Results]①The SYN immunostaining results were observed as yellow spots or granule-like deposits,which were characterized by a laminar distribution pattern in hippocampal formation of all model and control group rats. ②The density of synaptophysin positive immunoreactive product in hippocampal formation of model group was higher than the controls,especially in the mossy fiber layer of the area CA3 and the inner molecular layer of the dentate gyrus (P﹤0.05).[Conclusion]The increase of the expression of SYN probably makes the loading and release of the neurotransmitter easier,which may be correlative to the sustained aggravation of the status epilepticus.