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2011•Chinese Journal of General PracticeRequires access

Comparative Study of Escitalopram and Duloxetine in the Treatment of Depression

Fei Wen

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Abstract

Objective To compare the efficacy and safety of escitalopram and duloxetine in the treatment of depression.Methods 60 outpatients were randomly assigned to escitalopram group and duloxetine group with 8 weeks treatment.Each group included 30 cases.They were all diagnosed by CCMD-3.HAMD was used to assess the efficacy and TESS to assess the side effects.Results The efficacy at the point of week1,4,8 was 10.00%,83.33%,93.33% in escitalopram group,while 3.33%,63.33%,80.00% in duloxetine group.There was no significant difference between the efficacy in the two groups(P0.05).There was no difference between HAMD scores of two groups(P0.05).In escitalopram group,10% of cases had side effects,the rate was 16.7% in duloxetine group.The difference was not statistical significant.Conclusion Escitalopram was as effective and safe as duloxetine in the treatment of depression after 8 weeks' treatment.

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Objective To compare the efficacy and safety of escitalopram and duloxetine in the treatment of depression.Methods 60 outpatients were randomly assigned to escitalopram group and duloxetine group with 8 weeks treatment.Each group included 30 cases.They were all diagnosed by CCMD-3.HAMD was used to assess the efficacy and TESS to assess the side effects.Results The efficacy at the point of week1,4,8 was 10.00%,83.33%,93.33% in escitalopram group,while 3.33%,63.33%,80.00% in duloxetine group.There was no significant difference between the efficacy in the two groups(P0.05).There was no difference between HAMD scores of two groups(P0.05).In escitalopram group,10% of cases had side effects,the rate was 16.7% in duloxetine group.The difference was not statistical significant.Conclusion Escitalopram was as effective and safe as duloxetine in the treatment of depression after 8 weeks' treatment.

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Available abstract

Objective To compare the efficacy and safety of escitalopram and duloxetine in the treatment of depression.Methods 60 outpatients were randomly assigned to escitalopram group and duloxetine group with 8 weeks treatment.Each group included 30 cases.They were all diagnosed by CCMD-3.HAMD was used to assess the efficacy and TESS to assess the side effects.Results The efficacy at the point of week1,4,8 was 10.00%,83.33%,93.33% in escitalopram group,while 3.33%,63.33%,80.00% in duloxetine group.There was no significant difference between the efficacy in the two groups(P0.05).There was no difference between HAMD scores of two groups(P0.05).In escitalopram group,10% of cases had side effects,the rate was 16.7% in duloxetine group.The difference was not statistical significant.Conclusion Escitalopram was as effective and safe as duloxetine in the treatment of depression after 8 weeks' treatment.

Key concepts: Escitalopram, Duloxetine, Medicine, Hamd, Depression (economics), Duloxetine Hydrochloride, Significant difference, Clinical efficacy

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