Analysis on correlation between bacterial colonization of the lower respiratory tract and acute exacerbation of chronic obstructive pulmonary disease

Objective To analyze the correlation between bacterial colonization of the lower respiratory tract(LABC) and acute exacerbation of chronic obstructive pulmonary disease(COPD) in stable stage, so as to provide a basis for the prevention of such diseases, control and prognosis. MethodsClinical data of the patients with acute exacerbation of COPD admitted to Department of Respiration of Dongguan People's Hospital from July 2009 to June 2014 were retrospectively analyzed. The colonized bacteria cultured and pathogenic bacteria underwent comparison testing, homology analysis and testing of relevant indicators. ResultsThe bacteria cultured from the same patient with acute exacerbation of chronic obstructive pulmonary disease(AECOPD) in stable stage were mainly haemophilus genera, streptococcus pneumoniae and moraxella catarrhalis, and pseudomonas aeruginosa bacteria, and the bacteria homology was about 31.7%(39/123). Compared with COPD in stable stage, the patient had a significantly increased level of IL-8(P0.01). Compared with the group without bacterial colonization, the group with bacterial colonization had a significantly increased bacterial infection rate at lower respiratory tract(P0.05). Conclusion Part of the patients with COPD in stable stage had LABC, which to some extent can cause acute exacerbation of COPD. The airway inflammation of COPD in stable stage is relevant to the occurrence of LABC and IL-8 level.