Affection of Immunocomptence of bifidobactertum adolescentis on cyclophosphamide immune suppression mice

[Objective] To study the biological regulation and protective effect of the bifidobactertum adolescentis (BFA) on immune suppression mice. [Methods] Immune suppression mouse models were made by injecting cyclophosphamide in abdominal cavity of normal mice. 3 different concentrations of BFA were used to treat the mice of each group for 14 days. The index numbers of thymus, spleen and liver,the weight grow curve of mice, the CFU/g of BFA number, the white blood cell (WBC), content of IL-2 in blood were detected every day. SPSS 12.0 software was applied for data analysis. [Results] With the increasing treatment days, the index of thymus spleen and the dose of bifidobacterium (BFA) in bifidobacterium group were higher than other groups (P 0.05); there were changes of the CFU of BFA among model groups (P 0.05); the index of thymus, spleen and liver in bifidobacterium group are higher than other groups (P 0.05); there were changes of content of IL-2 and white blood cell (WBC) in each group. The weight curve also demonstrated that the high dose of bifidobaterium significantly increasd the weight of mice compared to the control group. (P 0.05). [Conclusion] BFA has the immunoregulation on experimental immune suppression mice.