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2013•Linchuang gandanbing zazhiRequires access

Current perspectives on the JAK/STAT signaling pathway and its activating factors in liver fibrosis

Ju Jia

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Abstract

The Janus kinase(JAK)/signal transducer and activator of transcription(STAT) signaling pathway is an important signal transduction pathway activated by a variety of cytokines and growth factors and mediates various cellular processes involved in liver fibrosis,including proliferation,differentiation,apoptosis,and inflammation.In this article,the recent findings related to the function of JAK/STAT signaling and its activating factors in liver fibrosis are reviewed.Specifically,the roles of three cytokines leptin,interferon-alpha(IFN-α) and interleukin-4(IL-4) are detailed in regards to their activation of the intracellular JAK/STAT pathway through the hepatic stellate cell membrane to promote expression of target genes involved in the fibrotic process.

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What this paper is about

The Janus kinase(JAK)/signal transducer and activator of transcription(STAT) signaling pathway is an important signal transduction pathway activated by a variety of cytokines and growth factors and mediates various cellular processes involved in liver fibrosis,including proliferation,differentiation,apoptosis,and inflammation.In this article,the recent findings related to the function of JAK/STAT signaling and its activating factors in liver fibrosis are reviewed.Specifically,the roles of three cytokines leptin,interferon-alpha(IFN-α) and interleukin-4(IL-4) are detailed in regards to their activation of the intracellular JAK/STAT pathway through the hepatic stellate cell membrane to promote expression of target genes involved in the fibrotic process.

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Available abstract

The Janus kinase(JAK)/signal transducer and activator of transcription(STAT) signaling pathway is an important signal transduction pathway activated by a variety of cytokines and growth factors and mediates various cellular processes involved in liver fibrosis,including proliferation,differentiation,apoptosis,and inflammation.In this article,the recent findings related to the function of JAK/STAT signaling and its activating factors in liver fibrosis are reviewed.Specifically,the roles of three cytokines leptin,interferon-alpha(IFN-α) and interleukin-4(IL-4) are detailed in regards to their activation of the intracellular JAK/STAT pathway through the hepatic stellate cell membrane to promote expression of target genes involved in the fibrotic process.

Key concepts: STAT protein, Janus kinase, stat, JAK-STAT signaling pathway, Signal transduction, Cancer research, STAT3, Janus kinase 2

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