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2002•Journal of Nankai UniversityRequires access

SYNTHESIS AND BIOLOGICAL ACTIVITIES OF α-(1H-1,2,4-TRIAZOL-1-YL)-β- ARYLAMINACRYLONITRILE

Huang Runqiu

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Abstract

A series of α-(1H-1,2,4-triazol-1-yl)-β-arylaminacrylonitrile 3a-3r were synthesized in good yield by the nucleophilic reaction of arylamines with α-(1H-1,2,4-triazol-1-yl)-β-dimethylamino-acrylonitrile hydrochloride 2. Their structures were confirmed by means of elemental analysis and 1H NMR, and E configurations were drawn from the data of 1H NMR. The preliminary bioassay results indicated that some of these compounds possessed fungicidal activities.$$$$

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A series of α-(1H-1,2,4-triazol-1-yl)-β-arylaminacrylonitrile 3a-3r were synthesized in good yield by the nucleophilic reaction of arylamines with α-(1H-1,2,4-triazol-1-yl)-β-dimethylamino-acrylonitrile hydrochloride 2. Their structures were confirmed by means of elemental analysis and 1H NMR, and E configurations were drawn from the data of 1H NMR. The preliminary bioassay results indicated that some of these compounds possessed fungicidal activities.$$$$

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Available abstract

A series of α-(1H-1,2,4-triazol-1-yl)-β-arylaminacrylonitrile 3a-3r were synthesized in good yield by the nucleophilic reaction of arylamines with α-(1H-1,2,4-triazol-1-yl)-β-dimethylamino-acrylonitrile hydrochloride 2. Their structures were confirmed by means of elemental analysis and 1H NMR, and E configurations were drawn from the data of 1H NMR. The preliminary bioassay results indicated that some of these compounds possessed fungicidal activities.$$$$

Key concepts: Acrylonitrile, Proton NMR, Bioassay, Chemistry, Yield (engineering), Elemental analysis, Nucleophile, Hydrochloride

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