Analysis on prenatal diagnostic results of chromosome karyotypes in 2068 fetuses

Objective:To explore the incidence of chromosomal diseases in fetuses by analyzing chromosome karyotypes on the high risk population of chromosomal diseases.Methods:2 068 pregnant women with high risk of chromosomal diseases in their fetuses underwent amniocentesis or percutaneous umbilical blood sampling from September 2003 to September 2008,then karyotypes of their fetuses were analysed.Results:68 fetuses were found chromosome abnormalities,the rate was 3.29%,including 44 fetuses of numerical abnormality and 19 fetuses of structural abnormality.Conclusion:Chromosomal karyotypes analysis on high risk population in the mid trimester of pregnancy is an important prenatal diagnosis method.Serum screening,B ultrasound screening and advanced maternal age are important measures to find fetus with chromosomal diseases.