Regional Sustained-release Chemotherapy Combined with Interventional Therapy in Treatment of Gastric Cancer

Objectives To explore the effect of 5-fluorouracil(5-FU) sustained release chemotherapy coupled with interventional therapy in treating gastric cancer(GC).Methods A total of 136 GC patients were divided into groups A(n=37,given chemotherapies of combined portal vein infusion and sustained-release 5-FU),B(n=34,given 5-FU chemotherapy),C(n=33,given portal vein infusion),D(n=32,given operation).All patients were given standard D2 radical surgery based on tumor sites and invading degrees,and 6-cycle FOLFOX6 chemotherapy regime 4 weeks after operation.Complications,adverse reactions and changes of blood and functions of liver and kidney were observed.Three-year survival rates recorded.Results All groups completed follow-ups,without loss to follow cases.The rate of hepatic metastasis and local failure was 4/37 in group A,10/34 in group B,10/33 in group C,18/32 in group D,the difference was significant(χ2=16.670,P0.05);thereinto lower in group A than in groups B,C,D(χ2=3.873,4.142,16.313,respectively,P0.05);lower in groups B,C than in group D(χ2=4.861,4.461,respectively,P0.05).Three-year survival rate was 34/37 in group A,25/34 in group B,24/33 in group C,15/32 in group D,the difference was significant(χ2=17.352,P0.05);thereinto higher in group A than in groups B,C,D(χ2=4.254,4.510,16.894,respectively,P0.05),higher in groups B,C than in group D(χ2=4.905,4.524,respectively,P0.05).Each group had complications and adverse reactions,not influencing curative effects.Conclusion Chemotherapy of combined portal vein infusion and 5-FU,easy to operate,safe and feasible with accurate positioning,can reduce the rate of hepatic metastasis and local failure of advanced GC patients and is worth generalizing and applying clinically.