A clinical study of the efficacy of a-interferon therapy for HBeAg negative chronic hepatitis B.

To investigate the effect ofα-interferon (INF-α)therapy for HBeAg-negative chronic hepatitis B (CHB). 30 cases with HBeAg-negative CHB were classified as treated group,while 52 cases with HBeAg - positive chronic hepati- tis B as control group.Both groups received injection of INF-αat dose of 6MU every other day for 24 weeks.Levels of al- anine aminotransferase,viral markers levels of HBeAg,HBV-DNA and the four serum fibrosis markers were analyzed be- fore and after treatment and 24 weeks after the course.There were 22 cases in treated group and 26 cases in control group who had got obvious therapeutic effects at the end of 24 weeks after treatment.And the rates of efficacy were separately 73.3% and 50%.The rate of treated group was higher than that of control group (x~2=4.267,P＜0.05).The four serum fibrosis markers of the both groups were clearly dropped after treatment(P＜0.05).INF-αat dose of 6MU in treatment for HBeAg-negative CHB is prior to HBeAg-positive CHB.And INF-αhave an evident function on preventing or dela- ying hepatic fibrosis in patients with CHB.