Effects of dexmedetomidine on sedation and hemodynamics in patients with hypertension during combined spinal epidural anesthesia

Objective To observe the effects of dexmedetomidine on sedation and hemodynamics in patients with hypertension during combined spinal epidural anesthesia.Methods Sixty patients with hypertension were divided into control group,dexmedetomidine group and propofol group,twenty cases in each group.The observer assessment of alertness/sedation(OAA/S) scores and systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR),respiration rate(RR),pulse oxygen saturation(SpO2) were recorded before anesthesia(T0) and 0(T1),5(T2),15(T3),30(T4) and 60 minutes(T5) after sedative administration.Results There was no statistical difference in the OAA/S score among three groups at T0-T1(P0.05).There was no statistical difference in the OAA/S score among T0-T5 in control group(P0.05).The OAA/S scores in dexmedetomidine group and propofol group were lower at T2-T5 than those at T0(P0.05).OAA/S scores were lower in dexmedetomidine group at T3-T5 and in propofol group at T2-T5 than those in control group(P0.05).There was no statistical difference in SBP,DBP,HR,RR and SpO2 among three groups at T0-T1(P0.05).In propofol group,SBP and HR at T3-T5 were significantly lower than those at T0(P0.05),DBP and RR at T4-T5 were significantly lower than those at T0(P0.05).In dexmedetomidine group,HR at T3-T5 was significantly lower than that at T0(P0.05).HR at T5 and RR at T4-T5 in propofol group were lower than those in control group(P0.05).SBP in propofol group at T4-T5 was lower than that in control group and dexmedetomidine group(P0.05).Conclusion Dexmedetomidine can obtain effective sedation stable hemodynamics in patients with hypertension during combined spinal epidural anesthesia.