Improved model of Autogenous Vein Graft Intimal Hyperplasia in Rats

Objective To explore the modified cuff technique to establish an animal model of intimal hyperplasia of autologous vein graf in rats.Methods Thirty-six SD rats were divided into experimental and control groups.The external jugular vein were implanted into the external carotid of the same side respectively by the anastomosis and the Cufftechnique in the experimental and control groups .The animals were given heparin(800 units/ kg, twice a day)for 5 days after the operation.The implannted the autogenous veins were observed respectively 2,4 and 8 weeks after the operation in the two group rats.Result The walls of the implanted autogenous veins were smoother in the experimental group than those in the control group .Conclusion The artery bypass graft estalished by cufftechnique is better than that by anastomosis technique.