Toxicologic Study on Fufang Xiaojingtong Capsule

ObjectiveTo abserve the acute toxicity in mice and the long-period toxicity Fufang Xiaojingtong Capsule(FFXT) in rats.MethodsThe maximum administration dosage(MAD) of FFDX were determined by iq administration in mice.80 SD rats were randomly divided into four groups: high,middle,and low dose of FFXT and control group.FFXT was continuously administrated for 90 days.When the experiment was finished and withdrawed for 14 days,rats were killed and the growth condition,blood cell counting and biochemical targets were measured.Histomorphological examination were simultaneously performed.ResultsThe MAD of FFXT by iq administration was greater than 40.0g/kg in mice.In the long-period toxicity test,the weight coefficients of livers,spleens,kidneys and testis were larger in high dose group than that of in control group.The punctiform necrosis in the liver were found in two rats for high dose group.The white pulp cells in spleen were rarefactively distributed in four rats for high dose group.The seminiferous tubule diameter of testis and the amout of seminiferous epithelial cells increased in male rats.Focal in terstitical cells of testis were propagated in male rats for middle dose group.The weight coefficients of testis were larger only in high dose group than control group at the 14 days after withdrawal.ConclusionIt could be concluded that FFXT is safe to be administrated in the dose prescribed.