Prevalence study of type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease in Shenyang city

Objective:To studying the risk factors of patients with type 2 diabetes mellitus (T2DM) complicated with non-alcoholic fatty liver disease (NAFLD).Methods:The physical examination data of 1800 cases for T2DM was analyzed. In which there were 360 (20%)patients with T2DM, they were divided into NAFLD (T2DM complicated with NAFLD)group (280 cases)and pure T2DM(control)group(80 cases).Analysis was conducted on the body mass index (BMI), waist hip ratio (WHR), fasting blood glucose (FBG), lipid, alanine transaminase (ALT), homeostasis model assessment-insulin resistance (HOMA-IR) and complications in the two groups.Results:The peak age of T2DM was 40～59 years old. The peak age of NAFLD was in mid-old persons, its prevalence in men (180 cases)was significantly higher than that of women (180 cases, P0.001), In NAFLD group, BMI[(27.1±2.1)kg/m2 vs. (22.9±2.0) kg/m2]、WHR[(1.4±0.1) vs. (0.9±0.3)]、FBG[(10.1±2.2)mmol/L vs. (8.9±2.3) mmol/L]、total cholesterol [TC, (6.3±1.5) mmol/L vs. (5.8±1.6) mmol/L]、ALT[(59.6±33.1U/L) vs. (27.4±11.7) U/L]、HOMA-IR[(5.1±1.3) vs. (3.4±1.2)]were significantly higher than those of the control group (P0.05 all). In NAFLD group, the patients complicated with obesity (53.1% vs. 27.9%), central obesity (80.3% vs. 44.7%) and hypertension (58.9% vs. 42.5%) were significantly higher than those in control group (P0.05 all). Logistic stepwise regression analysis indicated that HOMA-IR(OR=2.58,P0.01)、WHR(OR=2.66,P0.01) and BMI(OR=1.28,P0.05).Conclusion:The incidence rate of type 2 diabetes mellitus complicated with non-alcoholic fatty liver disease increases along with age, and it′s higher in men than that in women.The risk factors of this disease are body insulin resistance, central obesity and mass index.