The prostecdtive efficacy of actilyse intravenous thrombolysis in patients with acute cerebral infarction

Objective To evaluate the prostecdtive efficacy of Early Intravenous Thrombolysis using Actilyse (rt-PA) after one year in patients with acute cerebral infarction. Methods 137 of the 179 patients with acute cerebral infarction.after thrombolysis using Actilyse were followed up by telephone or home visit. the Chinese Stroke Scale (CSS) and Barthel Index (BI) were used to evaluate the neurological functions and life index in the one-year,two-years,three-years after the onset of strke. Results The significant effective rate of one-year in the group A, group B and group C were 83.67%,91.67% and 68.42%,there was 1significant difference between group A+B and group C;the curative rate of one year in the group A , group B and group C were 53.06%,52.08% and 31.57%,there was significant difference between the group A+B and group C;the significant effective rate of two-year in group A, group B and group C were 86.96%,89.13% and 71.43%,there was significant difference between the group A+B and group C;the curative rate of two-year in the group A,group B and group C were 56.52%,52.17%,31.43%,there was significant difference between the group A+B and group C;there was no significant difference between the group A+B and group C in the two-year effective rate,the three-year effective rate,the three-year significant effective rate and the three-year curative rate;there was no significant difference between the group A+B and group C in the one-year,two-year,three-year mortality rate, and no difference between group 0.7 mg/kg and 0.9 mg/kg、group Clexane and no Clexane.Conclusion the benefit of thrombolytic therapy using rt-PA intravenously in patients with acute cerebral infarction within 6 hours could last two years, after then,there was no significant difference between group A+B and group C.