2005•Chinese New Drugs JournalRequires access

Determination of cytidine disodium triphosphate and its related substances by RP-HPLC

Shi Nian-qiu

Abstract

Objective: A high performance liquid chromatography method was established to determine the related substances and degradation substances of cytidine disodium triphosphate Methods: the ODS colume(250mm×4.6mm,5μm) was used as stationary to elute phosphate buffer-acetonitrile was used as the mobile phase. The flowing rate was 1.0mL·min~(-1), detective wavelength was 254nm. Result: Chief peak and every impurity peak were seprated well. The theoretical plates number of cytidine disodium triphosphate was not below 3000. Conclusion: The method was proved to be sensitive and accurate, It's quite suitable to be used in the analysis of related substances of cytidine disodium triphosphate.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Cytidine, Chemistry, Elution, Acetonitrile, Chromatography, High-performance liquid chromatography, Impurity, Degradation (telecommunications)