ScholarLens Back to search
2000•Zhongguo yaolixue tongbaoRequires access

A model of carbon tetrachloride-induced hepatic fibrosis in mice

Jian Xu

Open publisher page 0 citations

Abstract

AIM To establish a model of carbon tetrachloride\|induced hepatic fibrosis in mice. METHODS Chronic adminstration of 20% carbon tetrachloride (CCl 4) was carried out in Kun\|Ming mice for 3 months, and then the changes of hepatic pathology and index of hepatic biochemistry observed as an interval of 30 days between experiments respectively. RESULTS The score of hepatic fibrosis and the content of hepatic hydroxyproline were gradually increased ( P 0 05～0 01). The content of molondiadehyde in liver monogenates and the activity of serumal aminotransferase were signifcantly higher than that of control groups in three observed stages ( P 0 01) either, but the rate of albumin in serum was signifcantly reduced only at the end stage of hepatic fibrosis in mice induced by CCl 4 ( P 0 05) CONCLUSION Chronic administration of CCl 4 to mice can induce histologically observable liver fibrosis with characteristic stages of hepatic fibrosis.

About this research paper

What this paper is about

AIM To establish a model of carbon tetrachloride\|induced hepatic fibrosis in mice. METHODS Chronic adminstration of 20% carbon tetrachloride (CCl 4) was carried out in Kun\|Ming mice for 3 months, and then the changes of hepatic pathology and index of hepatic biochemistry observed as an interval of 30 days between experiments respectively. RESULTS The score of hepatic fibrosis and the content of hepatic hydroxyproline were gradually increased ( P 0 05～0 01). The content of molondiadehyde in liver monogenates and the activity of serumal aminotransferase were signifcantly higher than that of control groups in three observed stages ( P 0 01) either, but the rate of albumin in serum was signifcantly reduced only at the end stage of hepatic fibrosis in mice induced by CCl 4 ( P 0 05) CONCLUSION Chronic administration of CCl 4 to mice can induce histologically observable liver fibrosis with characteristic stages of hepatic fibrosis.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

AIM To establish a model of carbon tetrachloride\|induced hepatic fibrosis in mice. METHODS Chronic adminstration of 20% carbon tetrachloride (CCl 4) was carried out in Kun\|Ming mice for 3 months, and then the changes of hepatic pathology and index of hepatic biochemistry observed as an interval of 30 days between experiments respectively. RESULTS The score of hepatic fibrosis and the content of hepatic hydroxyproline were gradually increased ( P 0 05～0 01). The content of molondiadehyde in liver monogenates and the activity of serumal aminotransferase were signifcantly higher than that of control groups in three observed stages ( P 0 01) either, but the rate of albumin in serum was signifcantly reduced only at the end stage of hepatic fibrosis in mice induced by CCl 4 ( P 0 05) CONCLUSION Chronic administration of CCl 4 to mice can induce histologically observable liver fibrosis with characteristic stages of hepatic fibrosis.

Key concepts: Carbon tetrachloride, Hydroxyproline, Hepatic fibrosis, CCL4, Internal medicine, Albumin, Fibrosis, Pathology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
A model of carbon tetrachloride-induced hepatic fibrosis in mice — Research Paper | ScholarLens